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IMPORTANT STATEMENT BY THE JBLC

Phosphofructokinase In Bearded Collies.

The Joint Breed Liaison Committee has recently been made aware of a Beardie that has been diagnosed with Phosphofructokinase (PFK) deficiency. This is an inherited condition resulting in an enzyme deficiency hitherto known in English Springer Spaniels, American Cockers, Wachtelhunds (German Spaniels), Whippets and mixed breed dogs. It is not an autoimmune condition.

This disease, does however, share many of the characteristics of regenerative autoimmune haemolytic aneamia and it is possible that Beardies which have been diagnosed and treated for AIHA may in fact have had PFK.

The symptoms of PFK are:
Weakness, depression, lethargy, exercise intolerance, stiffness, anaemia, (seen as paleness of the gums and other membranes), raised body temperature, jaundice and blood in the urine or dark coloured urine.
The disease often occurs following a period of stress such as hard exercise, heat stress, excessive panting or barking. As the disease is very similar to AIHA it may not be tested for by your vet as Beardies are not a breed thought to be predisposed to PFK but the clinical signs are very similar.

Several laboratories including the Animal Health Trust (AHT), offer a genetic test for PFK which is inherited as an autosomal recessive condition (ie 2 carriers are required to produce an affected) and we understand that the Beardie in question was tested by laboratory in America and found to be affected.

We have only just obtained some information regarding the pedigree of the dog concerned and we are now working, with the help of the AHT and the relevant breeders and owners, to validate the original DNA test, identify the gene mutation and try and determine the possible inheritance. We do not, however, know if this problem is confined to one line and so we are advising owners that PFK is considered by your vet should your dog be suspected to have regenerative AIHA and that those who have had dogs affected with regenerative AIHA consider testing them or their relatives for PFK status, (or any owners whose dogs exhibit similar signs to those given above and are concerned about their health).

We understand that a discount on testing is offered should 20 or more dogs be tested so if sufficient numbers are interested we can look at organising a clinic.

If you are interested in testing please contact our Breed Health Co-ordinator Elizabeth Ayrton (.(JavaScript must be enabled to view this email address) or Tel: 01539 444872 - by phone at weekends only)

We would also ask any owners that do undertake testing share the results - whether positive or negative with Elizabeth.

Fortunately this is a condition which in all probability can be removed from the gene pool with selective breeding, provided we are sensible and utilise the tests available. An established DNA databank would make detection of the lines involved so much easier, so once again we urge members to contribute samples - contact your Club JBLC member or the AHT for swabs.


We will, of course, share any further information as and when we are able.


The following links provide further information but if you have any queries please contact Elizabeth or any member of the Joint Breed Liaison Committee.


Links to further information on PFK:


http://ic.upei.ca/cidd/disorder/phosphofructokinase-pfk-deficiency

http://www.petmd.com/dog/conditions/endocrine/c_dg_phosphofructokinase_deficiency

http://www.essfta.org/english-springers/health-genetics-and-research-faq/phosphofructokinase-deficiency/

http://www.vetbook.org/wiki/dog/index.php/Phosphofructokinase_deficiency


Link to the AHT PFK test:


http://www.ahtdnatesting.co.uk/wp-content/uploads/2014/09/PFK-info-12-2-2014.pdf

For swabs for the DNA databank:

.(JavaScript must be enabled to view this email address) ( cost £5 per sample)
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JBLC Statement re Auto Immune in Beardies

Read the full report in Health section of web site..

JBLC Health Survey - Full and Final Survey and Summary

The JBLC Health Survey - Full and Final Survey and Summary are now available in the Health Section of the Clubs web site. .

DNA testing for CEA

THE BEARDED COLLIE BREED LIASON COMMITTEE

DNA TESTING FOR CEA

The JBLC has arranged a 20/20 clinic with OptiGen for DNA testing for CEA, which provides participants with a discount on the cost of the test. This discount is available until 10th May, and to take advantage you will require a unique code. The JBLC are running a testing clinic at NEBCC championship show in May, but those not able to attend the show can still take part.

The easiest way to obtain sample for DNA testing is via a cheek swab, however it is vital that the correct procedure is followed in order to obtain a suitable sample. Failure to do so will result in the swab being unsuitable for analysis and the added cost of repeating the test.

The cost of the OptiGen test itself is around $180 - minus the agreed discount of 20% plus a further 5% discount if you fill in the OptiGen forms online

If you are interested in taking part here's how:

If you are attending NEBCOL OR MIDSHIRES CHAMPIONSHIP Shows 2015:

• Contact Liz Gault tel: 01505 842462 (lochbarra@btinternet.com). Liz will provide you with the unique code required to obtain the discount.

• Fill out the forms on the OptiGen website (optigen.com) - we recommend that you read the 'Tips for successful online entry' on the OptiGen website to ensure you have all the correct information to hand before starting.

• Print off the forms and bring them and your dog to NEBCOL or MIDSHIRES CHAMPIONSHIP Shows 2015. Your dogs microchip will be verified and your dog will be swabbed by a vet and the forms countersigned.

• We will arrange for all the swabs collected at the show to be sent to OptiGen.

If you are not attending NEBCC show

• Contact Liz Gault tel: 01505 842462 (lochbarra@btinternet.com). Liz will provide you with the unique code required to obtain the discount and will send out swabs.

• Fill out the forms on the OptiGen website (optigen.com) - we recommend that you read the 'Tips for successful online entry' on the OptiGen website to ensure you have all the correct information to hand before starting.

• Print off the forms and swab your dog NB follow the procedure as given on the OptiGen website or arrange for your vet to do this. You will need another person to sign your form, confirming the dogs identity.

• Send your swabs to OptiGen as soon as possible - we recommended using Royal Mail International tracker service OR get someone who is going to NEBCC to bring them to the show ( but do not take the swabs more than a couple of days before the show)

Note: We are only able to arrange for a total of 50 dogs to be DNA tested, so first come first served! We may, however, run further clinics if demand is high.

Should you wish to have your dog blood tested rather than using swabs, OR if you have any other queries, please contact Liz Gault for further advice - note that for those not attending NEBCOL or MIDSHIRES shows there will be the additional costs of blood sampling and postage.

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JBLC CEA Statement 2014

JBLC_CEA_Statement_2014_.docx_.doc.

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